A Little Good…

A little good...

M y grandmother used to say, " If a little'll do a little good, a lot'll do a lotta good. " Unfortunately, it is not that simple with antiplatelet agents. Many relevant facts are well established. In identifiable subgroups of patients who present with transient ischemic attacks (TIAs) or minor strokes, the risk of a subsequent stroke is high. Most of this risk is incurred during the first few d...

Aging Well with a Little Wine and a Good Clock

Age-related decline in mammalian circadian rhythm has been recognized for decades, but the underlying molecular mechanisms have remained elusive. In this issue of Cell, Chang and Guarente use brain-specific SIRT1 knockout mice and transgenic mice overexpressing SIRT1 to develop an enticing model for how SIRT1 helps maintain the robustness of the aging circadian clock.

Where We Go with a Little Good Information

When observers move through an environment, they are immersed in a sea of motions that guide their further movements. The horizontal relative motions of all possible pairs of stationary objects fall into three classes: They converge, diverge and slow down, or diverge with increasing velocity. Conjoined with ordinal depth information, the first two motions reveal nominal invariants, constraining...

Good health has little to do with doctors, Mr Lansley.

Like a slippery fish, a little slime is a good thing: the glycocalyx revealed.

The glycocalyx is a dynamic network of multiple membrane-bound complexes lining the vascular endothelium. Its role in maintaining vascular homeostasis includes regulating vascular permeability as well as a range of vital functions, such as mechanotransduction, hemostasis, modulation of inflammatory processes, and serving as an antiatherogenic. Revisionist thinking about the Starling principle i...